The proceedings of the International Symposium on Open, Distance, and E-Learning (ISODEL 2021) share ideas, either research results or literature reviews, on distance education, media, and education in the digital era. Some recent issues consist of innovative education in the digital era, new media Industry 4.0, Digital Education Transformation, Character Building, Vocational Education 4.0, and Preserving Future Children Characters and Culture. It is expected that the proceedings will provide new insights to the knowledge and practice of education and education technology research. Therefore, such parties involved in education research such as academics, practitioners, business leaders, and others will benefit from the contents of the proceedings.