Published in association with the Annals of Family Medicine, The Wonder and the Mystery is an anthology of intimate personal stories and innovative ideas from the Annals' Reflections section. It includes a wide range of articles, from influential pieces on urgent topical issues to exceptional stories of unique individuals. These articles shed light on small moments and major life transitions. In the process, they help us find meaning in our own physical, emotional, and spiritual journeys. The one-of-a-kind stories and ideas in the book speak to all of us who are interested in health care and health, caring and connection: clinicians, patients, family members, researchers, policy makers, and more. The book reminds us that "the things we cannot measure may be the very things that will sustain us."