Summary of Dominic Smith's The Last Painting of Sara de Vos is a novel that describes the way two lives become intertwined through a mutual obsession with a seventeenth-century Dutch artist.

In the year 1957, wealthy New Yorker Marty de Groot realizes that his beloved painting, the only known surviving oil-on-canvas by seventeenth-century Dutch artist Sara de Vos, has gone missing. In its place over his bed is a fake. Hoping to get his revenge, Marty goes after the suspected forger, whom he later learns is a pretty, 20-something graduate student named Ellie Shipley. Little does Marty know that their meeting will end up having a profound effect on both of their lives.

During a charity event at his and his wife Rachel's penthouse on the Upper East Side, thieves steal into Marty's bedroom and take his de Vos, a 1636 painting titled At the Edge of a Wood...