This book reports on innovative system interfaces, with a special emphasis on their design, development and testing, and on improving the interaction and integration with the users. Focusing on the advantages and challenges of virtual, augmented and mixed reality systems, it describes novel interface technologies, together with cutting-edge strategies for improving usability and accessibility, and cover a wide range of applications from business organization to disaster and crises management, from smart manufacturing to assistive technologies and transportation. Based on the AHFE 2021 Conference on Human Factors and Systems Interaction, held virtually on July 25–29, 2021, from USA, the book offers a timely survey on systems interfaces for a more efficient and safer human-system integration, addressing systems engineers, UX researchers and technology users alike.