This Brief discusses impacts of the COVID-19 pandemic on the Portuguese tourism sector. Taking into account real-world conditions and the importance of the tourism sector for the Portuguese economy, this book highlights the economic contexts of tourism in Portugal at the regional and municipal levels, discussing pre-pandemic economic frameworks and projecting potential implications for the future. Using data provided by Statistics Portugal, the Brief performs econometric analysis on three cases: new paradigms for overnight stays and guests, changes in tourism revenues and prospective alternatives, and a comparison of effects on changes in number of guests and overnight stays at the regional level. Providing cutting edge analysis of a dynamic global situation, this Brief will be useful for researchers interested in tourism economics and European economics as well as policymakers and industry professionals.