Global and technological transformation is changing work and learning. A broader understanding of prevention and cultural change associated with it is putting new demands on companies and their employees. People and organizations need suitable competences to deal with this transformation. They need to be empowered to shape decent living and working conditions. Safety and Health Competence: A Guide for Cultures of Prevention is written in the context of work and health. The use of a social-constructive and a context sensitive approach to competence in occupational safety and health is new and forms a theoretical basis for putting into place the necessary learning processes for cultural transformation in companies and educational institutions.