The novel begins with a prologue in the voice of an old man, Charles de Cresseron, that is set in Chapelizod, Ireland, roughly a century after the events of the novel proper. This prologue details how, during an interment at the churchyard of the title, a skull is accidentally unearthed, which bears the marks of two crushing blows to the head and— even more disconcertingly— a small hole from a trepanning.