This volume aims at delivering the state-of-the-art scientific and clinical know-how for the management of patients with Connective Tissue Diseases (CTDs). With contributions from leading specialists from different disciplines, it presents the latest research findings on many aspects of the diseases in a clear, comprehensive way, and describes the most recent trends in treatment, such as the "treat to target" approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, and includes epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, the relationships with other disorders, and biological therapy. Readers will find this second volume to be an excellent source of information on the current understanding of CTDs, and clinical approach to CTD, clearly conveying the progress made in recent years. Connective Tissue Disease – A Comprehensive Guide Vol.2 will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these complex diseases.