Heads I Win, Tails You Lose chronicles the lives of long-married couple Anne, the dutiful wife and librarian, and Harold, the debonair professor and autocratic husband, as a devastating car accident changes their lives forever. Harold, rendered a quadriplegic, becomes demanding, petulant and more controlling than ever. The caregiver Mrs. Forester treats Harold with extraordinary kindness and tact. Is she an adversary or an accomplice? Anne is never sure. As the marriage and Harold's health disintegrate, Anne survives on the edge of despair. Following a chance meeting with a stranger that awakens her sexuality, she daydreams of escape. When the perfect solution presents itself, Anne steps into a world she never knew existed, and from which she can never return.