20-year-old Isabella from the state of Louisiana, USA, suffers from chronic heart muscle inflammation, which almost led to her death. It was only through the transplantation of the heart of a Mississippi housekeeper who died in a car accident that Isabella was given a second life. Even before the surgery, she felt this intense feeling in her heart of missing someone. This feeling gives her the idea to search for her unknown grandmother and eventually leads her to the neighboring state of Mississippi. There she meets 80-year-old Ava. A life-experienced, well-known writer with a sad past, of which no one suspects. It is only through Isabella's search for her biological grandmother that Ava's past slowly rises to the surface and is revealed, albeit not entirely voluntarily, thanks to Isabella's persistence.