Davey Devaney has hit rock bottom at Fort Gibson after losing most of his family during the forced Trail of Tears march and Indian Removals. He decides to stop drinking and go in search of his sole remaining brother, Johnny, who left the fort months earlier. He travels what he hopes is the same route Johnny took and when he finds his brother, their reunion is all he hoped to find. Still, his brother's found a wife and happiness, two things Davey craves. As he struggles to settle back into ordinary life along the rugged frontier, he finds he's attracted to a lovely young Scotswoman, Jenny, the adopted daughter of the storekeeper at the nearby settlement. What Fills the Heart follows the same family from The Marriage Cure with the unique blending of Cherokee and Irish culture.