This e-book of the International Journal of Sustainability in Higher Education (IJSHE) hopes to address the emerging implications of Institution of Higher Education's (IHE) engagement with Regional Centres of Expertise (RCE) efforts, by compiling the case studies of ten RCEs and highlighting divers "good practices" of IHEs involved with these RCEs in their major areas of activity (including policy and administration, campus operation, research and scholarship, education and teaching, and service to communities).