This book comprises the proceedings of the select peer-reviewed papers presented during the 18th Control Instrumentation System Conference (CISCON 2021). This book highlights the latest trends in instrumentation, sensors and systems, industrial automation and control, image and signal processing, robotics, renewable energy, power systems, and power drives. The research works covered in the book are of high quality and contributed by experts in academia and industry to provide meaningful direction for prolific growth. The book also features a few chapters contributed by the leading policymakers, technologists, farmers, and doctors who help outline the roadmap from the need for technology to policy-making to effect and implement technological advancements for the nation-building process. The book will serve as a valuable reference resource for academics and researchers across the globe.