Tremendous progress has been made in the war on cancer, leading to improvements in cancer prevention, detection, and treatment. Together, these advances have resulted in decreasing incidences and a steadily declining death rate from cancer. However, for patients who develop stage IV cancer, cancer that has spread to distant organs, their prognosis remains grim. Conventional chemotherapy is limited in its ability to successfully eradicate metastatic disease. Therefore, new modalities and approaches are desperately needed if we are to make progress toward conquering this last mountaintop of cancer research. This book lays out the rationale for a novel therapeutic strategy using new targeted drugs to develop effective ways to treat patients with metastatic cancer. This strategy uses artificial intelligence methods to leverage the vast amounts of genomic data that have become available in recent years to develop precise and personalized methods of treating patients with metastatic cancer. This strategy, together with modern approaches to immunotherapy, offers hope to the eventual routine cure of metastatic cancer.