This book explains in a practical and dynamic way the relevant aspects of quantitative research methodology in health sciences. It explores research paradigms, the foundations of evidence-based clinical practice, the formulation, through different models, of the research question and objectives, definition of the scope of study, population and sample, and the classification of research variables. The book also considers different quantitative research designs, distinguishing between observational studies and experimental studies, the main quantitative data collection techniques, including some guidelines for the validation of questionnaires, descriptive statistical analysis, and inferential analysis. It will allow the reader to understand, in a simple way, the phases of the scientific method applied to quantitative research in health, acquire basic and advanced skills for the development of a health research project from a quantitative perspective, and develop the conceptual phase with the definition of the research problem, its objectives, and working hypotheses.