Ferrara, 1505 AD. Talented Serafino is apprenticed to Mastro Filargiro, one of the city's leading artists.

Serafino finds love, but his mastery takes him on a perilous journey across Italy's feuding city-states, unaware that his virtuosity is a threat to the pre-eminence of the hitherto unchallenged masters of the Renaissance.

His life must take a dramatic new turn in the hope of escaping their enmity.

Washington DC, 2008. Parker's first year at Georgetown High is coming to an end.

His father is appointed Consul General in Florence. Parker enthusiastically embraces his new life and befriends handsome Beppe.

But almost everyone around him has been keeping secrets. And the fifteenth-century palazzo where his family now lives unexpectedly reveals its long-buried mysteries.

Separated by five hundred years, yet united by their talent, Serafino and Parker embark on similar journeys of discovery while fellow artists, assassins, princes and envious classmates rage and scheme around them.