Henry Wolfe has a penchant for finding trouble. Or more precisely trouble usually finds him. It is the late 1920s and Wolfe, a traveling reporter/self-proclaimed adventurer, is hired to go on a mission deep into the dubious jungles of Venezuela.

Several months earlier, the son of a wealthy family disappeared during his search for a lost tride who reportedly had found the key to eternal life. Wolfe is a last-minute replacement on the team to go find and extricate the son, no matter what.

No white man has ever gone down this Venezuelan river path and returned alive. Local tribesman and predators lurk in the leafy shadows as Henry and his team fight for their lives.