This book contains all refereed papers that were accepted to the first edition of the « Digital Enterprise Design & Management » (DED&M 2013) international conference that took place in Paris (France) from February 12 to February 13, 2013. (Website: http://www.dedm2013.dedm.fr/) These proceedings cover the most recent trends in the emerging field of Digital Enterprise, both from an academic and a professional perspective. A special focus is put on digital uses, digital strategies, digital infrastructures and digital governance from an Enterprise Architecture point of view. The DED&M 2013 conference is organized under the guidance of the CESAMES non profit organization (http://www.cesames.net/).