This book is designed to be primarily a resource book on clinical decision support systems for informatics specialists. Secondly, it is a textbook for teachers or students in health informatics. Finally, it offers a comprehensive introduction for clinicians, whether or not expert in the application of computers in medicine, who wish to learn about current developments in computer-based diagnostic systems. In addition, the book takes a novel look at CDS systems from the point of both the practitioner as well as the patient. In recent years, it has become obvious that, in addition to physicians, other health professionals have need of decision support. Therefore, the issues raised in this book apply to a broad range of clinicians. Building on the success of the 1998 edition this book once again brings together worldwide experts to illustrate the underlying science and day-to-day use of decision support systems in clinical and educational settings.