This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include:• Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine• Lessons from Sicilian centenarians for anti-aging medicine• Molecular biomarkers and genetic aspects of aging• Future of peptides in clinical practice• Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection• Tissue-specific autoantibodies in preventive medicine• Chronic stress as a psycho-neuro-immunological dysfunction• Gut-associated immune system and its health implications• Regenerative medicine with platelet-rich-plasma• Alzheimer's disease: Preventive and anti-aging neurology• Autistic spectrum disorder and mitochondrial medicine• Integrative hormonal approach in anti-aging medicine• Preventive cardiology and phlebology• Aesthetic and anti-aging medicine• Preventive ophthalmology• Preventive oncology• Nutrition in healthy aging• Physical activity and fitness paradigms for anti-aging and longevityRecommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new "standard of anti-aging medicine" and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.