High on the Vine features cousins Tami & Evi Maki, who often contemplate the shortcomings of their respective spouses, Toivo and Eino. The story is told through a series of short stories set in Upper Michigan. The Maki women contemplate how their lives may have fared (certainly better) had they not married the two louts. After a hideous winter survival weekend sponsored by the Maki men, Tami & Evi take over the boys' hunting camp as punishment. After various less than successful entrepreneurial ventures, the gals finally hit paydirt when they form a business deal with a brotherhood of monks to open a winery, which produces a barely potable wine dubbed "Monk Juice."

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