A brilliant boy, Sanjay sows the seeds of hope in his parents to escape the yoke of lower-middle-class life. He greatly contrasts his elder brother, Krishna with lower cognitive skills. A crush on a giggly, upright, and affectionate girl, Dimpy, a medical student, boosts Sanjay's spirit that slumped while he was at medical college. Notwithstanding his success, Sanjay faces a naked truth about the catastrophe he has created for himself. Dimpy jumps onto an unusual step to approach life from her own perspective.

When the Dominoes Fall revolves around the lives of Sanjay, Krishna, their parents, Dimpy, and many more.