Jamie Christmas tells the story of Jamie, a gothy elf who gets kicked out of the North Pole for being too weird and morbid. Together with her robotic assistant and friend, Death Leopard, she moves to the American countryside, where she meets a girl named Billy Jo and a boy named Seth; who just so happens to be the son of the Devil.

From there things get pretty crazy, and Jamie finds herself on a grand adventure involving involves sharks, demons, helicopter crashes, machine guns, communist elves, assassinations, bad puns, satirical critiques of evangelical Christian culture, mechanical spiders, teleportation, references to rock music, higher education, ghosts, a guy named Old Jim, very rude bouncy balls, and The True Meaning of Christmas ™.