Advanced practice nursing (APN) is an approach to further academic qualification for nurses that has been recognized worldwide by the International Council of Nurses since 2018, with the aim of combining practical nursing competence with scientific work. Particularly in clinical nursing practice, the demand for APN nursing experts is increasing. In this field, they support patient care, especially in areas with increased and complex nursing and monitoring needs, and ensure the quality of care. This book discusses the relevance of and areas of activity for APNs in specialized areas in hospitals.