After moving from Northern England for her university studies, Sienna Archer is now making a name for herself in London's business district, seemingly far away from where she started. Her personal life, however, is a different matter; apparently, being an independent woman with a career is still far from ideal when it comes to dating, and to add insult to injury, she is haunted by a betrayal in the past she cannot seem to shake, and that only reinforces her professional aspirations. A chance meeting with professional footballer Nicolo Di Luca on a business trip to Ancona drastically changes everything, and back in London, Sienna finds her rational, single-minded reality upended. Striving to follow her best friend's advice to move on as she battles with her past and what she truly wants out of her career, she gradually begins to question the choices she has made, and wonder whether a part of her heart never really left Italy. As the football season nears its culmination and unexpected challenges present themselves closer to home, Sienna must face her own demons and decide what truly matters. But is a spark enough to bridge not only geographical distance but also two completely different lives? Tango in Italian is a story of love, science and football, and about how following your heart can lead you to the most unexpected places.