<p>The ocean is central to the health of the planet and the well-being of human societies, but ongoing depletion, disruption, and pollution threaten its future. The United Nations proclaimed 2021-2030 the Decade of Ocean Science for Sustainable Development (UN Ocean Decade) in recognition of the need to sustainably manage the Ocean. U.S. participation in the Decade, guided by the U.S. National Committee, included a call for "Ocean-Shots" - ambitious, transformational research concepts that draw from multiple disciplines. More than 100 Ocean-Shots were submitted.</p> <p>Conducted at the request of the White House Office of Science and Technology Policy and sponsored by NASA, this report identifies exciting themes from the Ocean-Shots that will galvanize action and inspire transformative, cross-disciplinary, and multi-generational participation in the Decade. Two foundational themes undergird how to go about science: An Inclusive and Equitable Ocean calls for the involvement of a diverse and representative ocean community, and An Ocean of Data recognizes the shift toward open access for data that is collected. Four topical themes - The Ocean Revealed, The Restored and Sustainable Ocean, Ocean Solutions for Climate Resilience, and Healthy Urban Sea - represent promising areas for research investments that are consistent both with the UN Ocean Decade Outcomes and U.S. ocean priorities.</p>