This manual contains key elements of the Frontline In-Service Applied Veterinary Epidemiology Training (ISAVET) programme necessary for successful mentorship. The target of this Manual are individuals who are mentoring trainees enrolled in the Frontline (ISAVET) at the national level. This manual and a first of its kind, is intended to serve as an FAO Global resource for National capacity development of Veterinary Services to detect and respond to emerging infectious animal diseases including transboundary animal diseases and zoonotic diseases.