Jo Wheeler is pushed to the brink when bodies begin turning up on her lawn. When one of these things doesn't look like the others, she knows murder has entered the picture.

Other cases must also be solved, and when a night of routine surveillance goes south, and Jo is kidnapped by a nutjob with some lumber, her own life is on the line.

Murder Runs Amok encompasses the two weeks running up to Easter. Mama and Roger are putting an act together to try out for America's Got Talent. Pepper is doing her best to run the offices of Baranski and Wheeler Investigations and advertises for a new employee. Jackie quits her job with The Buxley Beacon to embark on a new adventure. And what's with Glenn wanting to have children with Jo as soon as possible?

As usual, life is never mundane for Jo and her family and friends in the town of Buxley, Ohio.