Dr Ishita Goenka, aware of a "flaw" in her horoscope, decides to accept her fate and create a life for herself that would make her proud and happy. On the other hand, business tycoon Kartik Mehra believes that it is one's karma that decides their fate.

As qismat brings Ishita and Kartik together, in the bond of holy matrimony, they try and accept each challenge that life throws their way. But what if the past that was long buried decides to come back and create havoc in their lives? And to add to that, time decides to test them, as they come face to face with the biggest tragedy of their lives.

Will they be able to survive the brunt of time and flourish, or will the same time create a rift in their relationship that will be unamendable?