The Rest Area Murder is the second book in the RV Mystery Series featuring Hank and Helen Moran. Hank, a recently retired robbery/homicide detective, and his wife Helen have just purchased a new motorhome and are once again ready to take a two-month-long tour to see the country. The investigation of the Leviticus murders during their trial run to Biloxi, Mississippi had put their tour temporarily on hold.

In this sequel to The Leviticus Mission, Hank decides to stop at an Indiana rest area for a state map to add to his collection. His decision to stop leads to a series of events that endangers both Hank's and Helen's lives.