Cowboy Bob Smith is a famous poker player whose career is cut short when he's murdered in a particularly grisly fashion. After a second poker player is killed in the identical manner, it seems as though a sick killer is on the hunt for world champion players. Noah Packard, a defrocked doctor-turned-detective, and his unlikely cohort a sharp-tongued ex-stripper, Jesica "One S", are hired to find the suspected serial killer, but they don't have much to go on. To find answers, the pair wades through a mire of gambling, racism, violence, and revenge, injected with a dose of the supernatural. They descend into the slimy underbelly of Las Vegas and the horrors of polygamous cults in Southern Utah, all while struggling to stop a killer before he strikes again.