When the plague known as Rot struck the world, crime lord Anthony Carrillo, known as El Jefe, moved operations to his Citadel in the wilderness, believing himself safe from both pestilence and the police. The Mexican police left him alone, but the American authorities were determined to arrest him, even though their own country was ravaged to the point of collapse. When a renegade doctor emerges from the desert offering El Jefe a way to defeat the plague and leverage the American authorities, dare he trust a man who may be a lunatic or a spy? Dare he not.