Compliance Management System (CMS) is a management tool that effectively supports compliant behavior in organizations. The integration of CMS related functions and measures into existing operational structures and processes enhance the effectiveness and efficiency of a sustainable development of your organization. ISO 37301:2021 "Compliance management systems - Require-ments with guidance for use" provides worldwide standardized re-quirements for the development, implementation, maintenance and continuous improvement of a CMS. The extent to which the requirements are implemented is to be flexibly adapted to the indi-vidual situation of each organization such as its risk exposure, size, industry, complexity of activities or legal form. The applica-tion to only a part of an organization is possible. The 2nd revised edition of this practical guide reflects the changes to the predecessor standard ISO 19600: 2014 "Compliance ma-nagement systems - Guidelines". Expanded with numerous new practical tips and examples, it supports compliance officers and everyone involved in the design and implementation of a CMS for any type of organizations. For executives and members of govern-ing bodies it serves as handbook to safeguard their duties of care for implementing adequate measures to prevent non-compliant behavior and to establish and maintain an effective compliance culture.