Aednat Wilson accidentally changes a transsexual into a real woman and also transfers all of her paranormal abilities into her as well. But creating her means that her own strength is weakened and Renee is now immortal. Renee has to deal with loving a man who will grow old and die while she stays 25 years old forever.
Once it is discovered that she is immortal, powerful people plot to gain the same for themselves. The label 'Witch' becomes a rallying cry for ignorant people who take literally the Bibles passage that says to "Kill Witches". The war against Witches has endured for centuries and now it is heating up because this Witch can fight back.