The need has always existed for entrepreneurial-minded health-care professionals to influence the sector by using business and leadership skills to create better access for our patients, reduce costs, and sustain or improve the quality of care to the satisfaction of the patient and their family. Postpandemic economy holds great potential for start-ups. Though the sector looks highly lucrative, it is still tricky to tread on these grounds. This brainchild of Christian Ehiobuche presents a comprehensive understanding of the U.S. health-care delivery system. It covers strictly professional and effective details of health-care entrepreneurship from business inception to establishment and further growth. It will take you on the journey of how to first identify as well as create opportunities in the health-care sector and then start, run, and grow a business. Discover the whole health-care business landscape regarding how to run a medical facility; develop digital health-care products; deal with insurance companies and processes, medical informatics, practice management, and growth strategy; and most importantly keep your sanity during this journey.