During Tony Toscotti's first year of college in the mid-1960s, his passion for scholarly pursuits—and for his first love Margaret—are completely and utterly squashed. The circumstances point to one responsible party: God, driving Toscotti to declare his own personal war on the Almighty. A novice combatant, Toscotti soon finds himself in unfamiliar territory, coping with a Vietnam-era Army boot camp, training as a helicopter pilot, and trekking Arctic and Antarctic trails blazed by polar explorers Franklin and Shackleton—ultimately discovering an elixir he believes could be the trump card in his crusade against Yahweh. Toscotti's best friend, Randy Chesterfield, a self-described prisoner of war, chronicles the saga while being held incommunicado by government forces intent on apprehending Toscotti's secret weapon to use for their own purposes. Along the way, Randy must confront his own justification for enlisting full-force in Toscotti's War.