Renee Chambers is a burgeoning germaphobe in search of a new job—something less stressful than her last job, teaching high school students. When her supposedly psychic best friend, Ellen, points her toward an odd little bookstore and a strange, otherworldly woman, Adrianne, Renee is thrown for a loop. One awkward interview and an even stranger psychic encounter later, Renee gets the job. Then Ellen's psychic dabbling has unintended consequences when Renee meets a pushy new friend, Katherine, a jealous ghost who's convinced they are soul mates.

A casino trip, a drunken drag show, an old beater of a car, and a pair of dinosaur panties push Renee to the edge, but the real kicker is when Katherine starts getting more insistent and borrowing bodies. All Renee wants is a peaceful, fledgling hermit existence, but that's unlikely unless she can figure out her true connection to Katherine, Ellen, and Adrianne. To discover the truth, she must come to terms with her past and learn how to embrace the future.