In the year 2071, humans must take daily dose injections to suppress the symptoms of the Styre virus that has infected the planet. When Finn Brantley loses his job, and with it, his access to a steady supply of daily injections, he comes to terms with his inevitable death. But when his doses run out and he's still alive, he's left with an impossibility—he's immune.

Eager to use his immunity for good, he begins to manufacture a vaccine using his blood, but government agents throw Finn in The 212, a prison built in what was formerly Lower Manhattan. There, he connects with rebel fighters who will help him at all costs.

Elsewhere, government agent Nolan Parker desperately searches for a cure for his daughter, only to uncover that the very government he works for knows more about the cure than it is letting on.

Two paths collide in the desperate search for a cure, a man's fight to save his daughter, and a way to liberate a country from the grips of a tyrannical government. As the characters fight to uncover the truth, they'll discover there is hope for a better future—even when all seems lost.