This book presents the papers included in the proceedings of the 2nd International Conference of Advanced Computing and Informatics (ICACIn'21) that was held in Casablanca, Morocco, on May 24–25, 2021. The main theme of the book is "Advances on Smart and Soft Computing." A total of 71 papers were submitted to the conference, but only 44 papers were accepted and published in this book. The book presents several hot research topics which include artificial intelligence and data science, big data analytics, Internet of Things (IoT), information security, cloud computing, networking and computational informatics.