My Ántonia is a novel published in 1918 by American writer Willa Cather, considered one of her best works. It is the final book of her "prairie trilogy" of novels, preceded by O Pioneers! and The Song of the Lark.

Set in rural Nebraska, Willa Cather's My Ántonia is both the intricate story of a powerful friendship and a brilliant portrayal of the lives of rural pioneers in the late-nineteenth century.

The novel tells the stories of an orphaned boy from Virginia, Jim Burden, and the elder daughter in a family of Bohemian immigrants, Ántonia Shimerda, who are each brought as children to be pioneers in Nebraska towards the end of the 19th century. Both the pioneers who first break the prairie sod for farming, as well as of the harsh but fertile land itself, feature in this American novel. The first year in the very new place leaves strong impressions in both children, affecting them lifelong.

This novel is considered Cather's first masterpiece. Cather was praised for bringing the American West to life and making it personally interesting.