The Department of SuperHuman Activities observes and polices the superpowered community in the United States. Through cooperation and open dialogue, the DSHA ensures the safety of superhumans and the public in general. Only during emergencies that regular law enforcement aren't equiped or trained to handle do they send in their emergency response team, the Operators. Led by Major Peter Hicks, the Hunter, and composed of superhumans from all over America, the Operators handle threates that others can't.

When people are killed in a series of strange animal attacks, the Operators are called to New Mexico to investigate. There, they discover a factory where monsters are made by an underground society of scientists and terrorists bent on world domination. The Operators are hard pressed to stop these monster makers in a war where safety is an illusion and not everyone will come out alive. Still, facing threats like this is their job, and it's time to get to work.