The hERG Cardiac Potassium Channel

ebook Structure, Function and Long QT Syndrome, Novartis Foundation Symposium · Novartis Foundation Symposia

By Derek J. Chadwick

cover image of The hERG Cardiac Potassium Channel

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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.

It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.

Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

The hERG Cardiac Potassium Channel
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