Dr. No is the sixth novel by the English author Ian Fleming to feature his British Secret Service agent James Bond. Fleming wrote the novel in early 1957 at his Goldeneye estate in Jamaica. It was first published in 1958. The novel centres on Bond's investigation into the disappearance in Jamaica of two fellow MI6 operatives. He establishes that they had been investigating Doctor No, a Chinese operator of a guano mine on the fictional Caribbean island of Crab Key.