Cal, Harlan, and Buddy grow up together in a small Virginia town in the years before the second World War. United by age, proximity, and temperament, they get into—and out of—all the trouble that boys manage to find. They even earn a nickname from a local restaurateur who gives the boys their first jobs and plenty of friendly advice. "Uncle" Vic calls them the Mulligans, because they always seem to find a way through a thicket of trouble—family problems, girls, college, war—to success. Cal and Harlan and Buddy have been blessed with second chances.

Now it's 1959, and police lieutenant Buddy receives an early-morning phone call: his friend Harlan, a store owner, has been shot in a break-in. Cal, now a preacher, meets Buddy at the hospital, and together, as professionals and as friends, they begin to unravel what might have happened to Harlan.