No parameter in diabetology - other than blood glucose - has gained the importance and popularity of glycated hemoglobin, also called HbA1c or A1C. The global aim of this book is to give proof to this statement. Major studies such as DCCT, UKPDS or ACCORD, but even more so every-day diabetes care, are driven by HbA1c as the crucial working tool. HbA1c likewise governs pathophysiology, education, epidemiology, guidelines and individual counselling. The author of this monograph was one of the pioneers in the field of HbA1c application and glycation research in Germany and accompanied HbA1c development from the solution of early-stage analytical problems to the exploration of its kinetics and later on to its standardization as an applied method in diabetes care. This textbook is of interest to those who are engaged in HbA1c or glycation in particular and in diabetes or metabolic syndrome in general.