Beloved by both Jack Kerouac and Neal Cassady, Lu Anne Henderson has never told her story. Lu Anne was a beautiful 15-year-old girl in Denver in 1945 when she met Neal, a fast-talking hurricane of male sexuality. The two married, and soon they were hanging out with a group of young would-be writers, including Jack Kerouac and Allen Ginsberg. But Neal and Jack initially didn't like each other. Lu Anne ended up loving them both, and she taught them how to love each other — giving Kerouac material for one of the seminal novels of the 20th century, On the Road. One and Only traces the immense struggles of Lu Anne's life, from the split-up of her family during the Great Depression to the ravages of abusive men and a late-life heroin addiction. It shows how her life intertwined with Jack's and Neal's to the very end.