This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation.Key Features* Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family* Explores immunodeficiencies, including:* Immunoglobulin deficiencies and B cells development* Glycosyl Phosphatidylinositol (GPI)-anchor and Paroxysmal Nocturnal Hemoglobinuria (PNH)* Investigates the links molecular pathology established between deficiencies in GPI-anchor synthesis and PNH* Includes the use of Multiple Antigen Peptides (MAPs) to induce protective immune response* Offers a timely update on Eosinophils' role in disease* Covers histology of Germinal center reaction of a spleen twelve days after primary immunization* Includes new research on cytotoxic T-lymphocytes* Presents the multiple roles of Nitric oxide (NO) in the inflammatory response