1903. Britain is desperate for change, but calls for social and gender reform flounder against entrenched misogyny. Navigating this world are friends Lena and Eliza – thoroughly modern young women determined to live life on their terms. Rumours swirl of barbaric experiments happening at London's medical schools. When the women covertly witness a brutal procedure performed on a semi-conscious dog, they swear to expose the perpetrator – renowned physiologist Dr Bayling. Their fight for justice draws the women into an increasingly vicious 'David & Goliath' war with a tyrannical, male, medical elite who will stop at nothing to preserve the status quo. But what are they prepared to risk? Their friendship, their loves, their freedom, even their lives?