Dr. Gerald O'Connor, known to friends as "Road Kill" O'Connor is a retired professor of archaeology and anthropology from Colorado State University. During his career, he became interested in animal skeletal structure and his penchant for collecting road-killed specimens in order to practice the skill of taxidermy earned him his nickname.

While watching the news one morning, he hears a report of a skull found along Interstate 90, not far from his home. There is no evidence of a body, only the skull. The only things authorities can tell is that the skull is likely that of an African American woman in her twenties and it has been there for many years.

Recalling a cold case in his vast collection of notebooks, O'Connor begins his search for information about this victim. An expert witness for law enforcement throughout his career, O'Connor begins to piece together other missing persons' cases and a pattern emerges. He concludes a serial killer has been at work for four decades. It's time this murderer was brought to justice and Road Kill O'Connor is just the man to get the job done.