Pythia is set in a dystopian future in which human cloning has been perfected; with men no longer biologically necessary, society has undergone radical change and become a matriarchy, with men serving as chattel and entertainment. In the name of redressing the injustices of the past, spirituality and traditional social structures are upended or forbidden, and the realm is governed by a tyrannical ruler who preserves her power through pseudo-science and appeals to fear and vengefulness. The protagonist, Simon Peter, is a gladiator who must hide his true beliefs in order to survive, as he struggles with other like-minded souls, male and female alike, to throw off the yoke of oppression and return human society to its former glory.

Will Simon Peter and his Freedom Fighters succeed? Will men and women live side by side? Or will the status quo prevail, leaving men, and the women who love them, living in fear and loneliness?